An adaptive nonparametric method in benchmark analysis for bioassay and environmental studies
نویسندگان
چکیده
منابع مشابه
An adaptive nonparametric method in benchmark analysis for bioassay and environmental studies.
We present a novel nonparametric method for bioassay and benchmark analysis in risk assessment, which averages isotonic MLEs based on disjoint subgroups of dosages. The asymptotic theory for the methodology is derived, showing that the MISEs (mean integrated squared error) of the estimates of both the dose-response curve F and its inverse F(-1) achieve the optimal rate O(N(-4/5)). Also, we comp...
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Bayesian Nonparametric Bioassay Estimation
Estimation of unknown pesticide levels in experimental samples is an important aspect of many agricultural and environmental studies. Such measurements are often made utilizing a “standard” dose response curve. This methodology compares the biological response of a target organism at known dosages to the response of the same organism exposed to an unknown sample. These “bioassays” are typically...
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ژورنال
عنوان ژورنال: Statistics & Probability Letters
سال: 2010
ISSN: 0167-7152
DOI: 10.1016/j.spl.2010.08.024